Open this entry in the complete research history
A lower mixture LC50 is not automatic proof of synergy
The evidence library is allowed to change in public. This page preserves the revised boundary, why it moved and which guides were affected.
What changed
The chemical-safety guide now includes the full 2014 acetaminophen and ibuprofen juvenile-mortality experiment while separating its ratio-specific curves from a formal mixture-interaction model and aquarium guidance.
Why it changed
The unequal series varied one drug while holding the other at 0.5 mg/L, but the reported LC50 labels include only the variable component. The paper used nominal concentrations and called patterns synergistic or antagonistic without a concentration-addition, independent-action, toxicity-unit, model-deviation or isobologram analysis.
Sources reviewed for this change
Affected practical guides
A public change is not automatically a retraction. A source may be added, a scope narrowed, a gap refined or an error corrected. The current guide and registry record own the current wording.
Follow or challenge the record
Subscribe to the research-update feed or submit a stable source and proposed correction.